INdermal presents Vegan DDS Recharge, a cosmetic ingredient developed to transfer advances in longevity science to topical skin care. Its formula combines two key molecules in cellular metabolism—NAD+ and NMN—with INdermal's nanovesicular delivery technology, designed to protect active ingredients and promote their availability in the viable layers of the skin.
In a context where trends such as Skin Longevity, Metabolic Beauty, and Biohacking are transforming cosmetic innovation, Vegan DDS Recharge proposes to go beyond the traditional wrinkle-focused approach. Its objective is to address biological processes related to skin aging, such as energy metabolism, cellular stress response, and DNA integrity.
NAD+ and NMN: two molecules, a complementary approach
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme for energy metabolism and participates in various cellular processes, including DNA damage response mechanisms. NMN (nicotinamide mononucleotide) is a direct precursor of NAD+ that intervenes in its natural production pathways.
Vegan DDS Recharge combines 1% NAD+ and 2% NMN, encapsulated in vegan deep-delivery nanovesicles. This technology is designed to protect the molecular integrity of both active ingredients and promote their transport to the viable layers of the epidermis, overcoming some of the challenges posed by their incorporation into topical cosmetic formulations.
Ex vivo results: protection of mechanisms associated with cellular longevity
The activity of Vegan DDS Recharge was evaluated in organotypic human skin explants subjected to UV-A radiation stress. In this experimental model, the formulation with 5% Vegan DDS Recharge showed outstanding results in several biological parameters:
- 95% protection of SIRT1, a protein related to cellular stress response and cell maintenance mechanisms.
- 88% protection against UV-A induced cellular senescence, evaluated using the p16 marker.
- 87% protection against alterations associated with DNA damage, evaluated using the γ-H2AX marker.
- 86% protection against cellular stress response, evaluated using FOXO3A levels.
- 66% recovery of cellular energy balance lost under UV-A stress, according to the ATP/ADP ratio.
The results support the potential of Vegan DDS Recharge to help preserve cellular mechanisms relevant to skin resilience.
Release Technology for Sensitive Actives
In addition to promoting the skin availability of NAD+ and NMN, encapsulation helps preserve their stability. In a four-week trial, NAD+ encapsulated in Vegan DDS Recharge showed protection against its loss of 55% at room temperature and 96% under refrigeration, compared to unencapsulated NAD+.
In an independent study of skin tolerance under dermatological supervision, a formulation with 10% Vegan DDS Recharge was evaluated in 10 volunteers. No erythema or edema was observed in any of the evaluations, and the average irritation index was zero.
With Vegan DDS Recharge, INdermal expands the formulation possibilities for serums, creams, ampoules, and other cosmetic treatments aimed at skin vitality and longevity. Its combination of NAD+, NMN, and advanced release technology offers formulators a tool to develop cosmetic proposals inspired by the science of longevity.