The rise of digitalisation has exacerbated people's desire to switch off and reconnect with their natural wellbeing. The circadian cycle is a critical factor in maintaining well-being. Provital has developed Circanblue™ as the first post-biotic cosmetic active that demonstrates integrated skin revitalisation in sync with our natural circadian rhythm after it has been disrupted by digital overexposure.
Recent studies demonstrate the presence of peripheral circadian clocks in the epidermis. This rhythm-generating molecular circuitry is mainly controlled by a feedback loop network of activators and repressors regulated by two key "clock genes": CLOCK and BMAL.
Ageing, changing seasons, variable sun exposure, fatigue, stress, insomnia, jet lag and blue light from electronic devices are responsible for small variations in circadian biorhythms. Since circadian biorhythm disturbances can affect the physiological metabolism of our skin, leading to signs of fatigue and skin ageing, Provital introduces Circanblue™. A natural active that truly "resets" the paradigm of the effects of digital stress on the skin.
Circanblue™ is a bioengineered cosmetic ingredient obtained through a plant-based fermentation of Lactococcus lactis. The resulting lab-grown lysate of this probiotic bacterium is both vegan and a post-biotic active. Provital has standardised its total protein content and analysed its resynchronising effects on the skin's circadian circadian cycle previously altered by exposure to artificial blue light.