What if your skin could activate its own regeneration and longevity mechanisms without needing to fast?
Science has made it possible. Imagine achieving brighter, smoother, and more even skin, with the desired glass skin effect, mimicking the benefits of cellular fasting... but without stopping to "nourish" your skin. CLARIVINE™, the latest innovation from Vytrus Biotech, redefines facial care through sustainable plant biotechnology.
We invite you to an exclusive free webinar in Spanish to discover CLARIVINE™ – Fasting for skin longevity, winner of the Innovation Award at in-cosmetics Global 2025. Reserve your spot here and learn firsthand how this innovation can transform your formulations with a revolutionary cosmetic solution that activates detox processes and cellular renewal, helping the skin to rejuvenate from within.
CLARIVINE™ embodies the convergence of two major industry trends: plant-based exosomes and advanced cosmetic biotechnology. This innovation was officially presented by the Vytrus team during in-cosmetics Global 2025 in Amsterdam, where they also shared their latest research on cosmetic applications of natural plant exosomes for skin and hair care.
In addition to this recognition, the active ingredients CENTELLA REVERSA™ and CAPILIA LONGA™ were also awarded at the prestigious BSB Innovation Awards 2025, an initiative led by Dr. Jan-H. Riedel that promotes excellence in cosmetic science worldwide.
The fasting factors of plants: a new approach to healthy skin aging
Developed from a biomimetic mechanism that reproduces the effect of cellular fasting on the skin, CLARIVINE™ is a 100% natural active ingredient derived from stem cells of Vitis vinifera (vine), a perennial plant with a remarkable capacity for regeneration and longevity. Vines can live for centuries thanks to their ability to adapt to environmental stress.
Through advanced plant biotechnology, CLARIVINE™ introduces an innovative biological approach to promote skin longevity by mimicking the molecular effects of cellular fasting. This mechanism triggers detox and rejuvenation processes at the cellular level, generating the desired glass skin effect and strengthening skin resistance in the long term.
The company has developed a unique approach inspired by the science of cellular fasting, widely recognized for its systemic health and longevity benefits, managing to induce a hormetic response in Vitis vinifera stem cells through controlled nutrient deprivation. This slight stress stimulates the production of a secretome rich in bioactive resilience compounds, defined as Plant Fasting Factors, consisting of:
- Polyphenols and secondary metabolites
- Signaling peptides and proteins
- Natural exosomes rich in peptides and exosomal resveratrol
These factors activate key regenerative pathways such as autophagy, telomere protection, and reduction of oxidative stress, improving cellular performance and promoting healthy aging from within. Skin cells gently enter renewal mode, detoxifying and rejuvenating naturally.
This mechanism visibly improves texture, tone, pigmentation, hydration, and the appearance of wrinkles in just 14 days. The result: more luminous, even, and smooth skin, with an immediate glass skin effect, supported by cellular longevity benefits scientifically validated in clinical studies conducted with multi-ethnic panels of Asian and Caucasian volunteers.
Vytrus has harnessed this natural intelligence by applying an intermittent fasting protocol to vine stem cells, stimulating them to produce a potent secretome. The result: a cutting-edge cosmetic active that unites two powerful market demands: skin longevity and glass skin aesthetics.
CLARIVINE™ represents a new frontier in skin care, offering formulators a sustainable plant-based solution for:
- Smoothing, illuminating, and radiance-boosting formulations
- Tone-unifying and pigmentation-reducing treatments
- Anti-wrinkle and hydration-improving applications
- Products with a glass skin effect for long-term healthy aging