Perricone MD Launches High Potency Triple Retinol Renewal Serum

It's a serum with three types of retinol that can be used both day and night, and whose results are noticeable from the first month

09 of October of 2025
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Perricone MD
Perricone MD

Skin concerns change with age, but almost all converge on the same point: the signs associated with aging. Over the years, the skin begins to show more visible wrinkles, loss of firmness, irregular texture, and a dull tone that detracts from the vitality of the face, neck, and décolleté. Added to this are other factors, such as sun exposure, pollution, or stress, which accelerate the breakdown of collagen and elastin fibers. And, as a consequence, the skin not only ages from the inside, but also visibly from the outside. "Retinol is the gold standard for anti-aging, however, there is still that fear of irritation, peeling, and redness. And that is precisely why Perricone MD has just launched a new serum: High Potency Triple Retinol Renewal Serum by Perricone MD, a day and night formula that presents retinol in a way never before seen and that can be used by all skin types," explains Mireia Fernández, dermocosmetic director of Perricone MD. "With this serum, which has the scientific endorsement of Dr. Nicholas Perricone, considered the third best dermatologist in the world, what we seek is to maintain the potency of retinol and that anyone can incorporate it into their daily routine,” adds Mireia Fernández, dermocosmetic director of Perricone MD.

#### Three retinols in a single formula

What is striking about the formula is, without a doubt, the retinol, which comes in triplicate. Perricone MD's new High Potency Triple Retinol Renewal Serum thus becomes a unique proposal that will mark a turning point in the use of retinols. “We have combined pure encapsulated retinol to ensure stability and avoid irritation, with a stable release system, together with retinol ester, which in itself ensures high compatibility with the skin. Added to this is retinART, a new bioreтиноide that is at the forefront and in many respects more effective than traditional retinols. Three forms that work in different ways to achieve more even, firm and luminous skin,” says Mireia Fernández, director of dermocosmetics at Perricone MD. 

THREE KEY RETINOIDS:

* **ENCAPSULATED PURE RETINOL:** The most active form of retinol, encapsulated to prevent skin reactions and ensure that the active ingredient is delivered to the cells gradually. * **RETINOL ESTER:** A fat-soluble form of retinol compatible with the skin that adds anti-aging activity and prevents irritation. * **RETINART:** At the forefront of retinoids, this molecule is extracted from algae, but its ability to produce collagen is even greater than that of retinol.

Altogether, she adds, "it achieves a global action that attacks wrinkles, fine lines, and loss of luminosity with a tolerance far superior to that of a retinol as we had known it until now."

The key to preventing irritation: soothing and protective actives

Innovation doesn't begin and end with triple retinol. The formula is designed so that the skin is not only renewed but also feels cared for and strengthened. "One of the challenges was to accompany the power of retinol with ingredients that hydrate, soothe, and protect the skin throughout the process," explains Fernández. Therefore, the serum includes "niacinamide and hyaluronic acid of different molecular weights, which guarantee deep hydration and elasticity, along with squalane to improve immediate softness," adds Mireia Fernández, director of dermocosmetics at Perricone MD.

Botanical extracts also play a very important role. "Raspberry, flaxseed, aloe vera, or chlorella are antioxidant and soothing allies. They strengthen the skin barrier and counteract any sign of irritation," says the dermocosmetics director of Perricone MD. Added to this are "ceramide NP, bisabolol, and allantoin, which reinforce the skin's protective function, and antioxidants such as coenzyme Q10, vitamin E, or alpha-lipoic acid, which curb the impact of oxidative stress," details Mireia Fernández, dermocosmetics director of Perricone MD.

The results speak for themselves

Clinical data supports the formula. After four weeks of use, 76% of the participants in a study showed a reduction in fine lines and an improvement in skin elasticity and resilience. 83% perceived more even and luminous skin, and 96% valued the serum's smoothness and lightness, without a greasy or heavy feeling. "These results reflect what we wanted to achieve: visible efficacy in a few weeks and, at the same time, a pleasant user experience," says Fernández.

Its texture is light and absorbs quickly. “It is applied after cleansing, with a gentle massage on the face and neck, and completed with a moisturizer suitable for the skin type. One of the advantages is that it adapts to different needs. It can be used globally on the entire face or as a localized treatment in areas with more pronounced wrinkles,” concludes Mireia Fernández, director of dermocosmetics at Perricone MD.