Special Chemicals, a company specializing in the development and distribution of cosmetic ingredients, presents SCH PeptCare™ AcTT11 OLIVE, a new peptide active designed to reinforce the dermo-epidermal junction (DEJ) by acting on three key mechanisms of skin aging: Syndecan-1 synthesis, Collagen XVII stabilization, and Collagen I production. The ingredient is oil-soluble and has an ISO 16128 natural origin index of 0.9999 and is especially indicated for anti-aging, firming, and redensifying formulations aimed at mature or structurally compromised skin.
The vast majority of cosmetic peptides available on the market are water-soluble, which limits their compatibility with oily phases and conditions the type of formulation in which they can be incorporated. Liposoluble peptides, on the other hand, remain scarce, even though many formulations (especially oily serums, balms, facial oils, and emulsions rich in lipid phase) would benefit from actives capable of naturally integrating into that environment. With SCH PeptCare™ AcTT11 OLIVE, Special Chemicals responds to this need by combining a liposoluble peptide with an equally bioactive vehicle matrix: olive oil rich in Omega-3, 6, and 9 fatty acids, hydroxytyrosol, and triterpenic acids (maslinic and oleanolic). The result is an ingredient in which the vehicle does not act as a simple inert carrier, but rather provides its own barrier functions, antioxidant defense, and support for cell renewal, in synergy with the action of the peptide.
In keratinocyte cultures, the active showed an upregulation of Syndecan-1 2.3 times higher than that of KGF, a growth factor used as a positive reference control, in addition to a dose-dependent regulation of COL17A1 expression, a gene involved in hemidesmosome anchoring. In aged skin fibroblasts, the active increased Collagen I synthesis more than 5 times compared to the control with TGF-β. These results are complemented by an in vivo study that showed statistically significant improvements in skin elasticity (+35%) and sustained hydration (+5.9%) after 60 days of use.
For more information or to request a sample, interested parties can contact the Special Chemicals sales team.